Cholic acid accumulation by the ciliary body and by the iris of the primate eye.
نویسنده
چکیده
Cholic acid accumulates in both the ciliary body and the iris of the primate eye during in vitro incubations at 37 degrees C for 1 hr. Incubation at 0 degrees C depresses uptake in both tissues. The washout of preaccumulated cholic acid occurs some 3.4 times faster from the iris than from the ciliary body. The mechanism of cholic acid accumulation in both tissues is less sensitive to inhibition by high iodipamide concentrations and also is less sensitive to inhibition by high hippurate concentrations than the mechanism of p-aminohippurate (PAH) accumulation. Therefore, although overlap may exist, the cholic acid--uptake mechanism differs from the PAH-uptake mechanism in both the primate ciliary body and the primate iris.
منابع مشابه
The transport of para-aminohippuric acid by the ciliary body and by the iris of the primate eye.
Para-aminohippuric acid (PAH) accumulates against a concentration gradient in the ciliary body and independently in the iris of the rhesus monkey eye. This accumulation is inhibited by incubation of 0 degrees C and shows saturation kinetics in both tissues. Cyanide, ouabain, dinitrophenol, iodopyracet, and probenecid effectively depress PAH uptake in both tissues, but anaerobic incubation condi...
متن کاملHistoanatomical study of the lens and ciliary body in ostrich eye
In the present study, the lenses and ciliary bodies of 20 ostrich eyes were studied macroscopically and microscopically. The histological slides were studied after staining by hematoxylin and eosin, Verhoeff, Van Gieson, and periodic acid-Schiff (PAS). Posterior surface of lens was more convex than its anterior surface. The average lens diameter and thickness were respectively measured as 1.43 ...
متن کاملCiliary Body Tuberculosis Presenting with Attacks of Acute Intraocular Pressure Rise
Purpose: To report a rare presentation of ophthalmic tuberculosis. Case Report: A 19-year-old man was referred to the glaucoma clinic due to multiple attacks of increased intraocular pressure (IOP) in his right eye. IOP of the right eye was 50 mmHg, and glaucomatous damage of the optic nerve was present. In gonioscopy, an oval-black lesion was present in the ciliary body band on the temporal si...
متن کاملAge variation of iodopyracet and iodide accumulation by the rabbit ciliary body-iris preparation.
In adult rabbits there is an active transport of ascorbic acid into the aqueous humor: the concentration of ascorbic acid in the anterior chamber is about 20 times that in plasma. In very young animals, however, the anterior chamber level differs little from the plasma level. Recently it has been demonstrated that iodopyracet (Diodrast) and iodide are actively transported out of the eye in vivo...
متن کاملAssociation of rs12913832 in the HERC2 Gene Affecting Human Iris Color Variation
Introduction: Human eye colour as a physical trait is based on the developmental biology and genetic determinants of the structure known as the iris, which is part of the uveal tract of the eye. Prediction of human visible characteristics (EVCs) by genotyping informative SNPs in DNA as biological witness opens up a new avenue in the forensic genetic. Variation of iris color rely on the amounts...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Investigative ophthalmology & visual science
دوره 18 8 شماره
صفحات -
تاریخ انتشار 1979